- NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.
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- Discovery of novel orally active ureido NPY Y5 receptor antagonists
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We have derived a novel series of neuropeptide Y (NPY) Y5 receptor antagonists from the biphenylurea 3. Cyclohexylurea 21c, a member of the series, is a potent NPY Y5 receptor antagonist that exhibits excellent pharmacokinetic parameters in rats and dogs. On chronic oral administration to diet-induced obese rats, 21c displayed an anti-obesity profile, causing a modest reduction in food intake, a significant decrease in body weight gain, a decrease in adipose mass, and an increase in lean tissue mass.
- Li, Guoqing,Stamford, Andrew W.,Huang, Ying,Cheng, Kuo-Chi,Cook, John,Farley, Constance,Gao, Jun,Ghibaudi, Lorraine,Greenlee, William J.,Guzzi, Mario,van Heek, Margaret,Hwa, Joyce J.,Kelly, Joe,Mullins, Deborra,Parker, Eric M.,Wainhaus, Sam,Zhang, Xiaoping
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p. 1146 - 1150
(2008/09/18)
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