SYNTHESIS OF HALOHYDROXYPYRAZINES AND THEIR SYNTHETIC UTILITY
Treatment of hydroxypyrazines with N-halosuccinimide (NXS; X=Cl, Br,I) in N,N-dimethylformamide (DMF) at room temperature afforded halohydroxypyrazines in good yields.Their synthetic utility was examined.
Aoyagi, Yutaka,Fujiwara, Takako,Ohta, Akihiro
p. 2407 - 2415
(2007/10/02)
2-Acyloxypyrazines. Convenient Acylating Agents for Amines
2-Acyloxypyrazines were found to be useful acylating reagents for amines.The preference of the acylation was for primary amines rather than secondary ones and also for aliphatic rather than aromatic ones.