- Synthesis and biological evaluation of benzofuran-based 3,4,5-trimethoxybenzamide derivatives as novel tubulin polymerization inhibitors
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A new series of derivatives characterized by the presence of the 3,4,5-trimethoxylbenzamide substituted benzofurans were synthesized and evaluated for antiproliferative activity against four cancer cell lines and one normal human cell line. Among them, de
- Chen, Lin,Chen, Zhi-Ru,Huo, Xian-Sen,Jian, Xie-Er,Li, Qiu,Li, Zi-Hua,Rao, Jin-Jun,You, Wen-Wei,Zhao, Pei-Liang
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supporting information
(2020/07/20)
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- Synthesis and evaluation of some novel essential amino acid-benzofuran-acetamide/propanamide/butanamide hybrids as potential anticonvulsant agents
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In this study, some new essential amino acid-benzofuran-acetamide/propanamide/butanamide hybrid derivatives were synthesized. The structures of the synthesized compounds were confirmed on the basis of their elemental and spectral analyses. Their anti-seizure activity was investigated using maximal electroshock seizure (MES) and subcutaneous metrazol (scMET) seizure tests in mice. Neurotoxicity (NT) of the synthesized compounds was also determined by the rotarod test. Derivatives exhibited favorable protection in both MES and scMET tests with high safety levels in NT test. The derivatives have proven significant activity in mice and could be suggested as potential anticonvulsant lead compounds. All leucine-chlorobenzoyl benzofuran-acetamide/propanamide/ butanamide hybrid derivatives (6b, 7b, and 8b) showed significant anticonvulsant activity in MES model. Compound 8b also demonstrated potent anticonvulsant activity against scMET test. The compound 8b showed maximum activity and would be considered as a lead for further optimization as anticonvulsant agent.
- Kamal, Mehnaz
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p. 283 - 289
(2020/09/18)
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- Novel organic compounds derivatives and organic light-emitting diode therewith
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The purpose of the present invention is to provide a novel organic compound in a specific structure having high efficiency, low driving voltage and long lifespan properties by being used in an electron transport layer of an organic light emitting diode. T
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Paragraph 0503-0506
(2018/05/03)
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- NOVEL HETEROCYCLIC COMPOUNDS AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME
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Disclosed are an organic heterocyclic compound represented by Chemical Formula A and an organic light-emitting diode comprising the same.
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Paragraph 0145; 0146; 0147; 0148; 0149
(2018/01/05)
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- Novel heterocyclic compounds and organic light-emitting diode including the same
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The present invention relates to a novel heterocyclic compound having long lifespan properties, low voltage driving properties, and excellent light emitting efficiency, and an organic light emitting device comprising the same and, more specifically, to an organic light emitting compound represented by any one selected from chemical formula A and chemical formula B, and an organic light emitting device comprising the same. In chemical formulas, each substituent of A1 to A4, Randprime;, Randprime;andprime;, X, Y, and Z, and n are the same as defined in the detailed description of the invention.COPYRIGHT KIPO 2016
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Paragraph 0430-0436
(2016/10/10)
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- BENZOFUROPYRIMIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND ITS USE
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PROBLEM TO BE SOLVED: To provide an electron injection material or an electron transport material driving an element under low voltage by excellent electron injection properties and electron transport properties under low pressure and further driving the element for a long time with high luminous efficiency. SOLUTION: Provided is an electron injection material or an electron transport material including a benzofuropyrimidine compound, for example, represented by formula (C-1). COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0141
(2016/10/09)
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- Synthesis, anticonvulsant and neurotoxicity evaluation of novel n-(2-benzoylbenzofuran-3-yl)-4-(substituted) butanamides
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A series of N-(2-benzoylbenzofuran-3-yl)-4-(substituted) butanamides (IVa-f) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. All the compounds was found active in MES tests. Compounds IVb, IVc, IVd and IVf were found to be potent and had activity at lower dose of 30mg/ kg in MES-test. Compounds IVa and IVe were less toxic as compared with the standard drug phenytoin.
- Kamal, Mehnaz,Shakya, Ashok K.
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- Condensed Azepine Derivatives As Bromodomain Inhibitors
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Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
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Page/Page column 44-45
(2012/08/27)
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- CONDENSED AZEPINE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
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Page/Page column 84-85
(2011/06/11)
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- Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof
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The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.
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Page/Page column 37-38
(2009/10/06)
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- Synthesis and analgesic activity of some 1-benzofurans, 1-benzothiophenes and indoles
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3-Unsubstituted 1-benzofurans 1e and 1f, 3-methyl-1-benzofurans 1a-1d, and 3-amino-1-benzofurans 2a-21, as well as 3-amino-1-benzothiophenes 3a, 3b and 3-aminoindoles 4a-4f, 11a, and 11b were prepared and tested as analgesics. The 3-amino-1-benzofurans 2 were prepared from the corresponding 2-hydroxybenzonitriles 5 and phenacyl bromides 6 via intermediates 7. Similar treatment of 2-sulfanylbenzonitrile (8) provided 3-amino-1-benzothiophenes 3. Appropriately substituted 2-aminobenzonitriles 9 then provided N-substituted 3-aminoindoles 4. 1-(Ethoxycarbonyl)indoles 4e and 4f were successfully deprotected giving indoles 11a and 11b, respectively.
- Radl, Stanislav,Hezky, Petr,Urbankova, Jitka,Vachal, Petr,Krejci, Ivan
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p. 280 - 296
(2007/10/03)
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- Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents
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An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.
- Habermann, Joerg,Ley, Steven V.,Smits, Rene
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p. 2421 - 2423
(2007/10/03)
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- Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists
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The discovery, synthesis and structure-activity relationships of a series of novel benzofuro[3,2b]pyridines as non-selective endothelin ET(A)/ET(B) as well as selective ET(B) receptor antagonists are described. The most potent non-selective inhibitor 7s d
- Mederski, Werner W. K. R.,Osswald, Mathias,Dorsch, Dieter,Christadler, Maria,Schmitges, Claus-Jochen,Wilm, Claudia
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p. 619 - 622
(2007/10/03)
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- Synthetic Studies in Benzofurans : Part XI - Synthesis of Some Benzofuropyridine Derivatives
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Synthesis of 2-acyl-3-aminobenzofurans from salicylonitrile and α-haloketones and their conversion into new tricyclic heterocycle benzofuropyridine derivatives through Friedlanders method are described.Some other routes for the synthesis of various
- Vaidya, V. P.,Mahajan, S. B.,Agasimundin, Y. S.
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p. 391 - 393
(2007/10/02)
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