2-Thiozebularine: Base modified nucleoside fully constrained in C3'-endo conformation in solution
2-Thiopyrimidinone ribofuranoside (2-thiozebularine, s2zeb) was synthesized by the adaptation of silyl method of N-glycosidic bond formation and using thionation of protected 2-oxonucleoside derivative (zebularine, zeb) with Lawesson reagent. T