497082-24-3Relevant articles and documents
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
da Costa Leite, Lucia Fernanda C.,Veras Mourao, Rosa Helena,de Lima, Maria do Carmo Alves,Galdino, Suely Lins,Hernandes, Marcelo Zaldini,de Assis Rocha Neves, Francisco,Vidal, Stephanie,Barbe, Jacques,da Rocha Pitta, Ivan
, p. 1263 - 1271 (2008/03/17)
New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-γ whose crystallographic structure is available on the PDB database
Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones
Mourao,Silva,Soares,Vieira,Santos,Lima,Lima,Galdino,Barbe,Pitta
, p. 1129 - 1133 (2007/10/03)
A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglycer