- A multiple hydrogen-bond scaffold based on dipyrimidin-2-ylamine
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equation presented A multiple hydrogen-bond array based on dipyrimidin-2-ylamine is presented, which is easily accessible. The influence of a preorganizing intramolecular hydrogen bond, tautomeric equilibria, and steric effects on the association behavior were investigated. X-ray diffraction shows that the molecules feature an ADA (acceptor-donor-acceptor) array of hydrogen-bonding sites in the solid state. The array persists in solution, and 1H NMR titrations show that molecules with sterically nondemanding DAD arrays are selectively bound. ? Eindhoven University of Technology. ? Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry.
- Soentjens, Serge H. M.,Meijer, Joris T.,Kooijman, Huub,Spek, Anthony L.,Van Genderen, Marcel H. P.,Sijbesma, Rint P.,Meijer
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p. 3887 - 3889
(2007/10/03)
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