- Pharmacochemistry of the furoxan ring: Recent developments
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In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.
- Calvino,Di Stilo,Fruttero,Gasco,Sorba,Gasco
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p. 321 - 334
(2007/10/02)
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- 4-Methyl-3-(arylsulfonyl)furoxans: A New Class of Potent Inhibitors of Platelet Aggregation
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A series of 4-methyl-3-(arylthio)furoxans were synthesized by oxidation of 1-(arylthio)-2-methylglyoxymes with dinitrogen tetroxide.Reduction with trimethyl phosphite of the furoxan derivatives afforded the corresponding furazans, while oxidation with an
- Calvino, R.,Fruttero, R.,Ghigo, D.,Bosia, A.,Pescarmona, G. P.,Gasco, A.
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p. 3296 - 3300
(2007/10/02)
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- Unsymmetrically Substituted Furoxans. VIII (1). Chloromethylfuroxans
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The two isomeric chloromethylfuroxans have been prepared.Their structures, thermal equilibration and reaction toward thiophenoxide ion are discussed.Kinetics of the 4-methyl--> 3-methyl isomer thermal conversion are also reported.
- Calvino, R.,Gasco, A.,Menziani, E.,Sefarino, A.
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p. 783 - 785
(2007/10/02)
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