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CAS

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49763-96-4

Stiripentol is a third-generation antiepileptic compound characterized as a white solid. It functions as a positive allosteric modulator of GABAA receptors, enhancing GABA-mediated activation, particularly in receptors with α3 subunits. Additionally, Stiripentol inhibits GABA reuptake and increases GABA release in neonatal rat hippocampal slices. It also exhibits inhibitory effects on lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5.

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  • 49763-96-4 Structure

  • Basic information

    1. Product Name: STIRIPENTOL
    2. Synonyms: Diacomit;(RS)-(E)-4,4-dimethyl-1-[3,4(methylenedioxy)-phenyl]-1-penten-3-ol;1-(Benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol;1-(1,3-BENZODIOXOL-5YL)-4,4-DIMETHYL-1-PENTEN-3-OL;STIRIPENTOL;1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-o;4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-o;4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol
    3. CAS NO:49763-96-4
    4. Molecular Formula: C14H18O3
    5. Molecular Weight: 234.29
    6. EINECS: 256-480-9
    7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles
    8. Mol File: 49763-96-4.mol

  • Chemical Properties

    1. Melting Point: 73-74°C
    2. Boiling Point: 365.4 °C at 760 mmHg
    3. Flash Point: 174.8 °C
    4. Appearance: white to beige/
    5. Density: 1.139 g/cm3
    6. Vapor Pressure: 5.54E-06mmHg at 25°C
    7. Refractive Index: 1.578
    8. Storage Temp.: -20°C Freezer
    9. Solubility: DMSO: ≥20mg/mL
    10. PKA: 14.45±0.20(Predicted)
    11. CAS DataBase Reference: STIRIPENTOL(CAS DataBase Reference)
    12. NIST Chemistry Reference: STIRIPENTOL(49763-96-4)
    13. EPA Substance Registry System: STIRIPENTOL(49763-96-4)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS: SB3393000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 49763-96-4(Hazardous Substances Data)

49763-96-4 Usage

Uses

Used in Pharmaceutical Industry:
Stiripentol is used as an antiepileptic drug for the adjunctive treatment of seizures associated with Dravet syndrome. It has been employed as co-therapy in the treatment of epilepsy, providing significant benefits when combined with other medications.
Used in Research and Analysis:
Stiripentol has been utilized in pharmacokinetic analysis and serves as a reference standard in fluorescence spectra analysis, contributing to the advancement of scientific understanding and development of new treatments in the field of epilepsy.

Biochem/physiol Actions

Anti-convulsant drug

Check Digit Verification of cas no

The CAS Registry Mumber 49763-96-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,7,6 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 49763-96:
(7*4)+(6*9)+(5*7)+(4*6)+(3*3)+(2*9)+(1*6)=174
174 % 10 = 4
So 49763-96-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+

49763-96-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • TCI America

  • (S0905)  Stiripentol  >98.0%(GC)

  • 49763-96-4

  • 1g

  • 1,190.00CNY

  • Detail

  • TCI America

  • (S0905)  Stiripentol  >98.0%(GC)

  • 49763-96-4

  • 5g

  • 3,990.00CNY

  • Detail

  • Sigma

  • (S6826)  Stiripentol  ≥98% (HPLC)

  • 49763-96-4

  • S6826-5MG

  • 724.23CNY

  • Detail

  • Sigma

  • (S6826)  Stiripentol  ≥98% (HPLC)

  • 49763-96-4

  • S6826-25MG

  • 2,925.00CNY

  • Detail

49763-96-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Stiripentol

1.2 Other means of identification

Product number -
Other names 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:49763-96-4 SDS

49763-96-4Upstream product

49763-96-4Relevant articles and documents

Central nervous system agents: new α ethylenic alcohols

Astoin,Marivain,Riveron,et al.

, p. 41 - 47 (2007/10/05)

The study of the sedative and anticonvulsive properties of a series of 1-alkoxyaryl 3-alkyl 1-alkene 3-ol and of the ketones from which they originate enabled us to select five compounds whose psychopharmacological effects were further studied. One of these compounds, 4,4-dimethyl 1-(3,4-methylene dioxy phenyl) 1-pentene 3-ol owns important anticonvulsive and sedative properties.

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