499195-60-7

Basic information

• Product Name: ethyl 4-(2-chloropyriMidin-4-yl)benzoate
• Synonyms: ethyl 4-(2-chloropyriMidin-4-yl)benzoate;Ethyl 4-(2-chloro-4-pyrimidinyl)benzoate;Benzoic acid, 4-(2-chloro-4-pyrimidinyl)-, ethyl ester
• CAS NO: 499195-60-7
• Molecular Formula: C₁₃H₁₁ClN₂O₂
• Molecular Weight: 262.69164
• Mol File: 499195-60-7.mol

Chemical Properties

• Melting Point: 120-124 °C
• Boiling Point: 442.9±28.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.83±0.20(Predicted)
• CAS DataBase Reference: ethyl 4-(2-chloropyriMidin-4-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(2-chloropyriMidin-4-yl)benzoate(499195-60-7)
• EPA Substance Registry System: ethyl 4-(2-chloropyriMidin-4-yl)benzoate(499195-60-7)

Safety Data

• Hazardous Substances Data: 499195-60-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-(2-chloropyrimidin-4-yl)benzoate is used as an intermediate in the synthesis of various medications for its potential biological activities.
Used in Medicinal Chemistry Research:
Ethyl 4-(2-chloropyrimidin-4-yl)benzoate is used as a valuable building block in drug discovery and development due to its unique structure and properties.
Used in Anti-inflammatory Applications:
Ethyl 4-(2-chloropyrimidin-4-yl)benzoate is used as an anti-inflammatory agent for its potential biological activities.
Used in Anti-tumor Applications:
Ethyl 4-(2-chloropyrimidin-4-yl)benzoate is used as an anti-tumor agent for its potential biological activities.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 38430-55-6 ethyl-4-acetylbenzoate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1056634-62-8 ethyl 4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoate 
• 1056635-40-5 4-(2-(4-morpholinophenylamino)-5-methylpyrimidin-4-yl)-2-methoxybenzoic acid sodium salt 
• 1056635-49-4 N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide 
• 1056634-68-4 Momelotinib 
• 945749-71-3 4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid 

Relevant articles and documents

N-CYANOMETHYLAMIDES AS INHIBITORS OF JANUS KINASE

The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant reject

PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

A novel and efficient synthesis of 4-phenyl-2-chloropyrimidines from acetophenone cyanoimines

A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier-Haack conditions to give the target compounds in moderate yields.