499794-59-1 Usage
Uses
Used in Pharmaceutical Industry:
(R)-3-amino-3-(o-tolyl)propanoic acid hydrochloride is used as an intermediate in the synthesis of pharmaceuticals for the treatment of neurological disorders such as epilepsy and depression. Its role in drug development is vital, as it contributes to the creation of new medications that can potentially improve the lives of patients suffering from these conditions.
Used in Research and Development:
In the pharmaceutical industry, (R)-3-amino-3-(o-tolyl)propanoic acid hydrochloride is also utilized in research and development. It aids scientists in understanding the properties and behavior of various compounds, which can lead to the discovery of novel drugs and therapies.
Used in Organic Chemistry:
(R)-3-amino-3-(o-tolyl)propanoic acid hydrochloride has potential applications in the field of organic chemistry. It can be used as a building block for the synthesis of new chemical compounds, contributing to the advancement of chemical research and the development of innovative materials.
Used in Biochemistry:
Similarly, in biochemistry, (R)-3-amino-3-(o-tolyl)propanoic acid hydrochloride can be employed for the synthesis of biologically active molecules. Its use in this field can lead to the creation of new compounds with potential applications in medicine and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 499794-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,9,7,9 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 499794-59:
(8*4)+(7*9)+(6*9)+(5*7)+(4*9)+(3*4)+(2*5)+(1*9)=251
251 % 10 = 1
So 499794-59-1 is a valid CAS Registry Number.
499794-59-1Relevant academic research and scientific papers
Enzymatic preparation of (S)-3-amino-3-(o-tolyl)propanoic acid, a key intermediate for the construction of Cathepsin inhibitors
Forro, Enik,Tasnadi, Gabor,Fueloep, Ferenc
, p. 8 - 14 (2013/07/19)
Enantiomerically pure (S)-3-amino-3-(o-tolyl)propanoic acid [(S)-6], identified as the preferred enantiomeric form for the construction of novel β-amino acid derivatives as inhibitors of Cathepsin, was prepared through both indirect and direct enzymatic strategies. Resolution of hydroxymethylated β-lactam (±)-1 through Burkholderia cepacia lipase PSIM-catalysed R-selective butyrylation (E > 200) was first carried out in t-BuOMe. Treatment of the unreacted (S)-1 with 18% HCl then furnished the desired (S)-6·HCl. Next, Candida antarctica lipase B catalysed the ring cleavage of racemic 4-(o-tolyl)azetidin-2-one [(±)-2] with excellent R enantioselectivity (E > 200), either in t-BuOMe with added H2O as nucleophile or in H2O at 60 C. Hydrolysis of the less reactive β-lactam enantiomer [(S)-2] with 18% HCl afforded (S)-6·HCl. A direct enzymatic route to enantiomeric (S)-6 was finally optimized through the lipase PSIM-catalysed S-enantioselective (E > 200) hydrolysis of racemic ethyl 3-amino-3-(o-tolyl)propanoate [(±)-3] in t-BuOMe with added H 2O at 45 C or in H2O at 3 C.
