500204-31-9

Basic information

• Product Name: ethyl 3-[7-[2-(3-methoxyphenyl)-2-oxoethoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoate
• Synonyms: ethyl 3-[7-[2-(3-methoxyphenyl)-2-oxoethoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoate
• CAS NO: 500204-31-9
• Molecular Formula: C₂₅H₂₆O₇
• Molecular Weight: 438.46974
• Mol File: 500204-31-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-[7-[2-(3-methoxyphenyl)-2-oxoethoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-[7-[2-(3-methoxyphenyl)-2-oxoethoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoate(500204-31-9)
• EPA Substance Registry System: ethyl 3-[7-[2-(3-methoxyphenyl)-2-oxoethoxy]-4,8-dimethyl-2-oxochromen-3-yl]propanoate(500204-31-9)

Safety Data

• Hazardous Substances Data: 500204-31-9(Hazardous Substances Data)

Upstream product

• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 251361-29-2 ethyl 3-(7'-hydroxy-4',8'-dimethyl-2'-oxochromen-3'-yl)propanoate 
• 608-25-3 2-methylbenzene-1,3-diol 
• 1501-06-0 diethyl 2-acetylglutarate 

Relevant articles and documents

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective inhibitors of the immunoproteasome are not only scarce, but also almost entirely restricted to peptide-based compounds. Herein, we describe nonpeptidic reversible inhibitors that selectively block the chymotrypsin-like (β5i) subunit of the human immunoproteasome in the low micromolar range. The most potent of the reversibly acting compounds were then converted into covalent, irreversible, nonpeptidic inhibitors that retained selectivity for the β5i subunit. In addition, these inhibitors discriminate between the immunoproteasome and the constitutive proteasome in cell-based assays. Along with their lack of cytotoxicity, these data point to these nonpeptidic compounds being suitable for further investigation as β5i-selective probes for possible application in noncancer diseases related to the immunoproteasome.

Synthesis of modified psoralen analogues

Substituted 3-(5-methyl-7-oxofuro[3,2-g]chromen-6-yl)propanoic acids analogous to psoralen were synthesized by linear annulation of a furan moiety to the coumarin system.