- Studies in antiparasitic agents: Part 20 - Synthesis of probenzimidazoles, benzimidazoles and purimidobenzimidazoles as possible anthelmintics
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A series of tetrasubstituted benzophenones (1-35) have been synthesized as probenzimidazoles.Some 2,5-disubstituted benzimidazoles (36-39 and 43-61) and pyrimidobenzimidazoles (40-42) have also been prepared.Of these compounds 4, 5, 15, 27, 29, 30, and 51 exhibit 100percent antihookworm activity against A. ceylanicum in hamsters at an oral dose of 250 mg/kg*3 while compounds 3, 4, 26-30 cause 100percent elimination of tapeworms, H. nana at a dose of 250 mg/kg.Compound 4 kills 90percent of the microfilariae of L. carinii at an intraperitoneal dose of 30 mg/kg*5.Another compound, 48 shows 6 4-78percent microfilaricidal and 38-62percent macrofilaricidal action against L. carinii and B. malayi at a dose of 50 mg/kg*5.
- Srivastava, Ravi P.,Singh, Sudhir K.,Abuzar, Syed,Sharma, Satyavan,Gupta, Suman,et al.
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p. 1035 - 1044
(2007/10/02)
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- Synthesis and Anthelmintic Activity of Bisbenzimidazole-2-carbamates
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The synthesis of bisbenzimidazole-2-carbamates (1-6) linked directly or by a one-atom bridge (CH2, CO, O, SO2, or S) at the 5 positions is described.Compound (4) shows interesting anthelmintic activity.
- Viswanathan, N.,Joshi, B. S.,Gawad, D. H.,Gokhale, U. B.,Sidhaye, A. R.,Rajasekariah, G. R.
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p. 730 - 732
(2007/10/02)
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