Research on the pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters
The pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters is described. Generally, the PLE-catalyzed enantioselective hydrolysis of prochiral diesters affords the corresponding half-esters in high yield, beca
Intramolecular photoreaction of thiobarbiturates with an alkenyl or a benzyl group in their N-alkyl side chain. Regioselective synthesis of ring-fused pyrimidine derivatives through photocyclization of mono- and dithiobarbiturates
Upon irradiation, thiobarbiturates with an alkenyl (4,5) or a benzyl (14,15,21) group in their N-alkyl side chain give bi- and tri-cyclic fused pyrimidine derivatives through regioselective [2+2] photocycloaddition or Norrish type II reaction, respectively.