501121-89-7

Basic information

• Product Name: benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate
• Synonyms: benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate
• CAS NO: 501121-89-7
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.28968
• Mol File: 501121-89-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate(501121-89-7)
• EPA Substance Registry System: benzyl 8-oxa-4-azabicyclo[5.1.0]octane-4-carboxylate(501121-89-7)

Safety Data

• Hazardous Substances Data: 501121-89-7(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 1226779-54-9 benzyl dibut-3-enylcarbamate 
• 132365-02-7 N-benzyl-N-(but-3-enyl)-but-3-en-1-amine 
• 1247884-42-9 benzyl 4-methanesulfonyloxyazepane-1-carboxylate 
• 501121-88-6 benzyl 2,3,6,7-tetrahydro-1H-azepine-1-carboxylate0 

Downstream Products

• 1440955-42-9 benzyl 2-methyl-4,5,7,8-tetrahydrooxazolo[4,5-d]azepine-6-carboxylate 
• 1440955-41-8 4-acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester 
• 1440955-40-7 4-acetylamino-5-hydroxy-azepane-1-carboxylic acid benzyl ester 

Relevant articles and documents

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Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

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NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

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Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology i