Truce-Smiles rearrangement of substituted phenyl ethers
The requirement of aryl ring activation by strong-electron withdrawing substituents in substrates for the intramolecular nucleophilic aromatic substitution reaction known as the Truce-Smiles rearrangement was examined. Preliminary mechanistic experiments
Kosowan, Joel R.,W'Giorgis, Zemane,Grewal, Ravneet,Wood, Tabitha E.
p. 6754 - 6765
(2015/06/25)
Synthesis and biological evaluation of new non-imidazole H 3-receptor antagonists of the 2-aminobenzimidazole series
A novel series of non-imidazole H3-receptor antagonists was developed, by chemical modification of a potent lead H3-antagonist composed by an imidazole ring connected through an alkyl spacer to a 2-aminobenzimidazole moiety (e.g., 2-