- Antituberculosis compounds and preparation method and applications thereof
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The invention provides antituberculosis compounds and a preparation method and applications thereof. Concretely, the invention provides the compounds presented by the formula I which is shown in the description, or pharmaceutically acceptable salts or solvates thereof, pharmaceutical compositions of the compounds, the preparation method and the applications of the compounds in preparation of medicine for treating tuberculosis. An action site of the compounds of the invention is aspartate-semialdehyde dehydrogenase (ASD), has a novel action mechanism, and can be used for the development of novel anti-drug resistant MTB anti-tuberculosis medicine.
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