- The synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5a(14C)] pyrimidine-2-carbaldehyde from [14C]aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate
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Hydrazination of barium [14C]cyanamide and hydrazinolysis of S-methylisothio[14C]urea were compared for their ability to efficiently prepare [14C]aminoguanidine bicarbonate. [ 14C]Aminoguanidine bicarbonate was converted in three steps to 5, 7-dimethyl-1,2,4-triazolo[1,5a(14C)]pyrimidine-2-carbaldehyde, a key radiochemical GMP starting material. Copyright
- Rane, Anil M.,Klaas, Schildknegt
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scheme or table
p. 257 - 260
(2011/05/06)
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