- PROCESS FOR MANUFACTURING AN EPOXIDE
-
Process for manufacturing an epoxide by reacting at least one chlorohydrin with at least one dehydrochlorinating agent in order to give the epoxide and at least one chlorinated co-product, said process comprising regenerating the dehydrochlorinating agent from the chlorinated co-product by a treatment which does not comprise an electrolysis operation.
- -
-
Page/Page column 26-30
(2015/07/07)
-
- BORON OR ALUMINUM COMPLEXES
-
The present invention relates to boron and aluminum complexes, to the preparation thereof, and to the use thereof for solubilizing ionic compounds. The complexes have one of the following formulae: in which D represents B or Al; R1 represents R, RF, NO2, CN, C(═O)OR, RSO2, or RFSO2; —X1—, —X2—, —X3— and X4 each represent a divalent group >C═O, >C═NC≡N, >C═C(C≡N)2, >CR2R3 or >SO2; —Y1—, —Y2— and —Y3— each represent a divalent group —O—, >N(C≡N), >N(CORF), >N(SO2R4), >NR4, >N(COR4) or >N(SO2RF); R, R2 and R3 each represent H, an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, an oxaalkyl group or an alkenyl group; R4 represents an alkyl group, an aryl group, an alkylaryl group, a heteroaryl group, an arylalkyl group, an oxaalkyl group, an alkenyl group or an RFCH2— group; RF is a perfluoroalkyl group, a partially fluorinated alkyl group, or a partially or totally fluorinated phenyl group; each of the R′2 and R′3 groups represents R or F.
- -
-
Page/Page column 23
(2011/08/02)
-
- SYNTHESIS OF ISOMERIC N-(3-FLUORO-2-HYDROXYPROPYL) AND N-(2-FLUORO-3-HYDROXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES
-
Reaction of fluoromethyloxirane (III) with heterocyclic bases in the presence of potassium carbonate afforded N-(3-fluoro-2-hydroxypropyl) derivatives of adenine (VI), 3-deazaadenine (VII), 2-amino-6-chloropurine (XII), 6-nitro-1-deazapurine (IX), 4-methoxy-2-pyrimidone (XVIII) and its 5-methyl derivative (XIX).Acid hydrolysis of compounds XII, XVIII, and XIX gave 9-(3-fluoro-2-hydroxypropyl)guanine (XIII), 1-(3-fluoro-2-hydroxypropyl)uracil (XX) and -thymine (XXI).The intermediates XVIII and XIX were ammonolyzed to give 1-(3-fluoro-2-hydroxypropyl)cytosine (XXII) and -5-methylcytosine (XXIII).Reaction of chloro derivative XII with sodium azide followed by hydrogenation of the formed 2-amino-6-azidopurine (XIV) led to 9-(3-fluoro-2-hydroxypropyl)-2,6-diaminopurine (XV), 9-(3-fluoro-2-hydroxypropyl)-1-deazaadenine (X) was obtained by hydrogenation of compound IX.Benzyloxymethyloxirane (XXIV) was reacted with pyridine-hydrogen fluoride adduct to give 3-benzyloxy-2-fluoropropanol (XXV) whose tosylate XXVI on reaction with sodium salt of adenine and subsequent hydrogenolysis of the intermediate XXVII afforded 9-(2-fluoro-3-hydroxypropyl)adenine (XXVIII).The same compound was obtained by reaction of 3-benzoyloxy-1-bromo-2-fluoropropanol (XXX) with sodium salt of adenine followed by methanolysis.Condensation of sodium salt of XI, XVI, and XVII with synthon XXX and subsequent acid deblocking gave 9-(2-fluoro-3-hydroxypropyl)guanine (XXXIII), 1-(2-fluoro-3-hydroxypropyl)uracil (XXXVI), and 1-(2-fluoro-3-hydroxypropyl)thymine (XXXVII). 1-(2-Fluoro-3-hydroxypropyl) derivatives of cytosine (XXXVIII) and 5-methylcytosine (XXXIX) were obtained by ammonolysis of the corresponding 4-methoxypyrimidine intermediates XXXIV and XXXV.
- Jindrich, Jindrich,Dvorakova, Hana,Holy, Antonin
-
p. 1466 - 1482
(2007/10/02)
-
- BROMOFLUORATION DES ALCOOLS ALLYLIQUES PAR NBS/Et3N, 3HF : UNE VOIE SIMPLE D'ACCES AUX EPIFLUORHYDRINES
-
Bromofluorination of allylic alcohols using a combination of N-bromosuccinimide and triethlyamine tris-hydrofluoride gives the vicinal fluorobromohydrins.The treatment of the formed fluorobromohydrins with aqueous sodium hydroxide constitutes a convenient route to epifluorohydrins.
- Chehidi, Ikram,Chaabouni, Mohamed Moncef,Baklouti, Ahmed
-
p. 3167 - 3170
(2007/10/02)
-
- The Combination of Potassium Fluoride and Calcium Fluoride: A Useful Heterogeneous Fluorinating Reagent
-
The combination of potassium fluoride and calcium fluoride was found to be an effective and practical solid reagent for the fluorination of various organic chlorides and bromides under mild conditions.
- Ichihara, Junko,Matsuo, Toshiya,Hanafusa, Terukiyo,Ando, Takashi
-
p. 793 - 794
(2007/10/02)
-
- Reactions of Oxygenated Radicals in the Gas Phase. Part 12. The Reactions of Isopropylperoxyl Radicals and Alkenes
-
The co-oxidation of trans-2,2'-azopropane and some aliphatic alkenes has been studied between 303 and 408 K.From the yields of molecular products, rate data have been obtained for the reaction of isopropylperoxyl radicals and the following alkenes, 2-methylbut-2-ene, 2-methylbut-1-ene, 2-methyl-propene, propene, and 3-fluoropropene (reaction (22)).It is shown that the isopropylperoxyl radical is less reactive than methylperoxyl but still shows distinct electrophilic character in these reactions.
- Sway, Mohammed I.,Waddington, David J.
-
p. 139 - 144
(2007/10/02)
-
- Reaction Modes of Fluorination of Cyclic Ethers by Potassium Fluoride-18-Crown-6
-
The reaction scheme of the chlorine substitution of epichlorohydrin or 3,3-bis(chloromethyl)oxetane by potassium fluoride-18-crown-6-was elucidated by the aid of selectively deuterated compounds.
- Kawakami, Yuhsuke,Yamashita, Yuya
-
p. 3930 - 3932
(2007/10/02)
-
- Process for preparing aldehydes from oxirane compounds
-
Aldehydes are prepared by reacting an oxirane compound with hydrogen peroxide in the presence of a boron compound.
- -
-
-
