503065-61-0

Basic information

• Product Name: 5-(2,5-dimethylbenzylidene)-2-thioxo-4-imidazolidinone
• Synonyms: 5-(2,5-dimethylbenzylidene)-2-thioxo-4-imidazolidinone
• CAS NO: 503065-61-0
• Molecular Formula: C12H12N2OS
• Molecular Weight: 232.30148
• Mol File: 503065-61-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2,5-dimethylbenzylidene)-2-thioxo-4-imidazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-dimethylbenzylidene)-2-thioxo-4-imidazolidinone(503065-61-0)
• EPA Substance Registry System: 5-(2,5-dimethylbenzylidene)-2-thioxo-4-imidazolidinone(503065-61-0)

Safety Data

• Hazardous Substances Data: 503065-61-0(Hazardous Substances Data)

Upstream product

• 503-87-7 2-thiohydantoin 
• 5779-94-2 2,5-dimethylbenzaldehyde 

Relevant articles and documents

Antimycobacterial activity of 5-arylidene derivatives of hydantoin

The synthesis of various 5-arylidene-2-thiohydantoins and results of the primary assay in vitro for their antimycobacterial activity is reported. Eight of those compounds exhibited >90% inhibition of Mycobacterium tuberculosis growth and for them the minimum inhibitory concentrations, cytotoxicity (IC50) and the selectivity index values were determined. The most active structure, (5Z)-5-(1,1′-biphenyl-4-ylmethylene)-2-thioxoimidazolidin-4-one, showed MIC=0.78 μg/ml. For all compounds logP and logD (pH 6.5) values were calculated.