- Synthesis of chiral C2-symmetric 1,10-phenanthrolines from naturally occurring monoterpenes
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A convenient procedure for the preparation of chiral C2-symmetric 1,10-phenanthrolines bearing a chiral framework in the form of a cycloalkeno-condensed substituent in the 2,3- and 8,9-positions of the heterocycle is reported. Starting from the 2-benzyloxycyclohexanone, four 1,10-phenanthrolines derived from (-)-β-pinene, (+)-α-pinene, (-)-isopinocampheol, and (+)-camphor were prepared according to a method based on a double Michael-azaannulation-aromatization sequence.
- Chelucci, Giorgio,Loriga, Giovanni,Murineddu, Gabriele,Pinna, Gerard A.
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