503536-77-4 Usage
Uses
Used in Organic Synthesis:
5-[4-(Dimethylamino)phenyl]-2-pyridinamine is utilized as a reagent in organic synthesis, where its distinctive structure and reactivity contribute to the formation of complex organic molecules. Its role in this application is crucial for the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-[4-(Dimethylamino)phenyl]-2-pyridinamine serves as a precursor in the synthesis of a variety of pharmaceuticals. Its unique chemical properties make it a valuable component in the creation of new drugs, potentially leading to advancements in medical treatments.
Used in Agrochemicals:
5-[4-(Dimethylamino)phenyl]-2-pyridinamine is also employed as a precursor in the synthesis of agrochemicals, indicating its broad applicability in the development of products that contribute to agricultural productivity and pest control.
Used in the Creation of Fluorescent Dyes:
5-[4-(Dimethylamino)phenyl]-2-pyridinamine is used as a building block in the development of fluorescent dyes. These dyes are essential tools in various research and diagnostic applications, including the study of biological processes and the detection of specific molecules within complex systems.
Used in Biomedical Research for Imaging Agents:
Furthermore, 5-[4-(Dimethylamino)phenyl]-2-pyridinamine is integral to the creation of imaging agents for biomedical research. Its incorporation into imaging agents aids in the visualization of biological structures and processes, enhancing our understanding of disease mechanisms and the effectiveness of therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 503536-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,5,3 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 503536-77:
(8*5)+(7*0)+(6*3)+(5*5)+(4*3)+(3*6)+(2*7)+(1*7)=134
134 % 10 = 4
So 503536-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H15N3/c1-16(2)12-6-3-10(4-7-12)11-5-8-13(14)15-9-11/h3-9H,1-2H3,(H2,14,15)
503536-77-4Relevant articles and documents
Discovery and in Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor
Chen, Xing,Yan, Yaoyao,Zhang, Zhaoyan,Zhang, Faming,Liu, Mingming,Du, Leran,Zhang, Haixia,Shen, Xiaobao,Zhao, Dahai,Shi, Jing Bo,Liu, Xinhua
, p. 11857 - 11885 (2021/09/02)
Cathepsin C (Cat C) participates in inflammation and immune regulation by affecting the activation of neutrophil serine proteases (NSPs). Therefore, cathepsin C is an attractive target for treatment of NSP-related inflammatory diseases. Here, the complete discovery process of the first potent "non-peptidyl non-covalent cathepsin C inhibitor"was described with hit finding, structure optimization, and lead discovery. Starting with hit 14, structure-based optimization and structure-activity relationship study were comprehensively carried out, and lead compound 54 was discovered as a potent drug-like cathepsin C inhibitor both in vivo and in vitro. Also, compound 54 (with cathepsin C Enz IC50 = 57.4 nM) exhibited effective anti-inflammatory activity in an animal model of chronic obstructive pulmonary disease. These results confirmed that the non-peptidyl and non-covalent derivative could be used as an effective cathepsin C inhibitor and encouraged us to continue further drug discovery on the basis of this finding.
False positives in a reporter gene assay: Identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase
Heitman, Laura H.,Van Veldhoven, Jacobus P. D.,Zweemer, Annelien M.,Ye, Kai,Brussee, Johannes,Ijzerrnan, Adriaan P.
supporting information; experimental part, p. 4724 - 4729 (2009/06/18)
Luciferase reporter-gene assays are a commonly used technique in high-throughput screening campaigns. In this study, we report on a luciferase inhibitor (1), which emerged from an antagonistic G protein-coupled receptor luciferase reporter-gene assay scre
