- Rearrangement in the synthesis of annulated lactams starting from benzothiazines
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The conversion of methoxyamides based on iminic 1,4-benzothiazines has led to three different products depending on the substitution pattern. On the one hand, different types of unknown lactam systems with and without a rearrangement under ring contraction of the benzothiazine substructure were selectively obtained. In this investigation, annulated lactams without ring contraction were formed by oxidation of the sulfide group to a sulfone group in the benzothiazine skeleton. On the other hand, benzothiazoles, which are oxidation products, were isolated. The structures of all types of lactams were verified by X-ray diffraction.
- Stalling, Timo,Saak, Wolfgang,Martens, Juergen
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- Direct α-Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism
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Alcohols were found to be arylated directly at their α-C?H bond with aryl halides in the presence of a base and a substoichiometric amount of t-BuOOt-Bu through a homolytic aromatic substitution mechanism. (Figure presented.).
- Aoki, Kohei,Yonekura, Kyohei,Ikeda, Yuko,Ueno, Ryota,Shirakawa, Eiji
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p. 2200 - 2204
(2020/05/05)
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