- Synthesis of 1,5-Anhydro-D-fructose derivatives and evaluation of their inflammasome inhibitors
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Synthesis of several 1,5-Anhydro-D-fructose (1,5-AF) derivatives to evaluate inhibitory activities of the inflammasome was carried out. Recently, 1,5-AF reported to suppress the inflammasome, although with only low activity. We focused on the hydration of
- Goto, Kohtaro,Ideo, Hiroko,Tsuchida, Akiko,Hirose, Yuriko,Maruyama, Ikuro,Noma, Satoshi,Shirai, Takashi,Amano, Junko,Mizuno, Mamoru,Matsuda, Akio
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supporting information
p. 3763 - 3772
(2018/07/13)
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- BICYCLIC MORPHOLINO COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
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The present invention provides bicyclic morpholino compounds and oligomeric compounds prepared therefrom. More particularly, incorporation of one or more of the bicyclic morpholino compounds into an oligomeric compound is expected to enhance one or more p
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Paragraph 0452
(2016/08/03)
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- HALOGENATED DIDEOXY SUGAR DERIVATES, PREPARATION METHOD AND APPLICATION THEREOF
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A halogenated dideoxy sugar derivative, having the following general structure I wherein X is halogen, R1 and R2 are H or Br; R3 and R4 are OH or OAc. The compounds 1-14 of the current invention has strong inhib
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Page/Page column 7
(2012/11/13)
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- HALOGENATED DIDEOXY SACCHARIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
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The current invention is related to a halogenated dideoxy sugar derivative, wherein that the derivative has the following general structure I wherein X is halogen, or R1 and R2 are H or Br; R3 and R4 are OH or O
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Page/Page column 8; 10
(2012/12/13)
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- Development of carbohydrate-derived inhibitors of acid sphingomyelinase
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The acid sphingomyelinase is an emerging drug target, especially for inflammatory lung diseases. Presently, there are no directly-acting potent inhibitors available for cell-based studies. The potent inhibitor phosphatidylinositol-3,5-bisphosphate (PtdIns3,5P2) is not only unsuited for cell culture studies, but also does not provide hints for further structural improvements. In the SAR study described here, we replaced the inositolphosphate moiety by a carbohydrate derivative and the phosphatidic acid residue by an alkylsulfone ester. The resulting compound is more active than its parent compound and offers new means for further structural modification.
- Roth, Anke G.,Redmer,Arenz, Christoph
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supporting information; experimental part
p. 939 - 944
(2010/05/02)
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- Synthesis of UDP-glucose derivatives modified at the 3-OH as potential chain terminators of β-glucan biosynthesis
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A series of UDP-d-glucose derivatives and precursors that have been modified at C-3 were synthesised from d-glucose as potential chain terminators of β-glucan biosynthesis. None of the UDP-derivatives or the precursors tested displayed significant anti-fungal activity in a series of germination assays on the dermatophyte Trichophyton rubrum.
- Danac, Ramona,Ball, Lucy,Gurr, Sarah J.,Fairbanks, Antony J.
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p. 1012 - 1022
(2008/09/20)
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