cas 50488-42-1, 2-Bromo-5-(trifluoromethyl)pyridine | Articles data ｜lookchem

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50488-42-1

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Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids
As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
Cottet, Fabrice,Marull, Marc,Lefebvre, Olivier,Schlosser, Manfred
p. 1559 - 1568
(2007/10/03)

Trifluoromethyl-substituted pyridines through displacement of iodine by in situ generated (trifluoromethyl)copper
A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3- and 4-iodopyridines or 2-bromopyridines are used as the starting materials. WILEY-VCH Verlag GmbH 2002.
Cottet, Fabrice,Schlosser, Manfred
p. 327 - 330
(2007/10/03)

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Chemical Properties

Appearance/Colour :Light yellow needles
Melting Point: 44-48 °C
Boiling Point: 209.3 °C at 760 mmHg
Flash Point:80.4 °C
Density: 1.707 g/cm³
Solubility:Soluble in methanol and ethanol.
Storage Temp.:Room temperature.
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.572
PKA: -1?+-.0.10(Predicted)
PSA: 12.89000
LogP: 2.86290

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