Silver-Catalyzed Site-Selective Ring-Opening and C-C Bond Functionalization of Cyclic Amines: Access to Distal Aminoalkyl-Substituted Quinones
Distal aminoalkyl-substituted quinones have been efficiently prepared through silver-catalyzed site-selective deconstruction and C-C bond transformation of unstrained N-acylated cyclic amines. This method enjoys mild reaction conditions, high selectivity, a broad scope of substrates, and a low catalytic loading of silver. This strategy can also be applied to the modification of peptides bearing cyclic amine residues.
FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated inimunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
-
Page/Page column 100
(2012/11/06)
More Articles about upstream products of 505088-49-3