- Stable carteolol hydrochloride, preparation method thereof and eye medicine combination
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The invention relates to stable carteolol hydrochloride, a preparation method thereof and an eye medicine combination, in particular to a method for preparing carteolol hydrochloride. The method comprises the following steps of preparing 3-amino-2-cyclohexenone, tetrahydro-2,5(1H, 6H)-quinolinone, 5-hydroxy-3,4-dihydro-2(1H)-carbostyril and 5-(2,3-epoxypropoxy)-3,4-dihydro-2(1H)-carbostyril, and then the carteolol hydrochloride is obtained. Furthermore, the invention provides the carteolol hydrochloride crude medicine obtained according to the method, the eye medicine combination prepared by using the obtained carteolol hydrochloride as the crude medicine, and applications of the obtained carteolol hydrochloride to preparation of drugs for treating or preventing glaucoma or ocular hypertension. The method has excellent pharmaceutical characteristics, for example, the obtained crude medicine and a preparation has excellent stability.
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Paragraph 0120; 0125; 0137; 0148; 0159; 0169; 0170; 0181
(2017/12/06)
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- One-pot synthesis of 3,4-dihydropyridin-2-one via michael addition of in situ-generated enaminones
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Herein we have reported a facile solvent-, catalyst-, and aldehyde-free, one-pot synthesis of 3,4-dihydropyridin-2-one from 1,3-diones using simple and mild reaction conditions. The substrate scope has been also extended to β-ketoesters.
- Senthil Kumar,Kumari, Neeta,Luthra, Pratibha Mehta
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supporting information
p. 3010 - 3019
(2013/09/12)
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- Pharmaceutical compositions containing quinolin-2,5-diones, new quinolin-2,5-diones and processes for the preparation thereof
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This invention relates to pharmaceutical compositions containing quinolin-2,5-diones of formula STR1 wherein A, B, R1 to R3 and X are defined hereinbelow, some of which are novel, which compounds have valuable pharmacological propert
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