- Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent
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In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)- octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity.
- Zhang, Hong-Yan,Yamakawa, Yu-Ichiro,Matsuya, Yuji,Toyooka, Naoki,Tohda, Chihiro,Awale, Suresh,Li, Feng,Kadota, Shigetoshi,Tezuka, Yasuhiro
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p. 604 - 608
(2014/01/23)
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- A PROCESS FOR PREPARING LONG CHAIN SATURATED OR UNSATURATED OXYGENATED COMPOUNDS
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A process for preparing long chain saturated or unsaturated oxygenated compounds. The process for the preparation of long-chain saturated or unsaturated oxygenated compounds having from 20 to 36 carbon atoms, selected from the group consisting of polycosanoic acids, their alkyl esters, polycosanols and corresponding compounds having an unsaturated hydrocarbon chain comprises the operation of reacting, in accordance with the Wittig or Peterson olefination reaction, a phosphorus ylide RP(Ar)3, wherein R is a saturated or unsaturated hydrocarbon chain containing one or more ethylenic and/or acetylenic unsaturations and Ar is aryl, or the corresponding α-silylcarbanion, respectively, with an n-alkanoic acid, formylated in the terminal position, or with its corresponding alkyl ester.
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- HEPTATRIACONTAN-4-ONE, TETRATRIACONTANYL OCTACOSANOATE AND OTHER CONSTITUENTS FROM PEDALIUM MUREX
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Key Word Index - Pedalium murex; Pedaliaceae; fruits; heptatriacontan-4-one; tetratriacontanyl octacosanoate; pentatriacontane; hexatriacontanois acid; hentatriacontanoic acid; ursolic acid; vanillin. Two new compounds isolated from the fruits of Pedalium murex are characterized as heptatriacontan-4-oneand tetratriacontanyl octacosanoate by spectral studies.Pentatriacontane, sitosterol, hexatriacontanoic acid, hentriacontanoic acid, ursolic acid and vanillin have also been isolated and identified.
- Shukla, Yogendra N.,Thakur, Raghunath
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p. 973 - 974
(2007/10/02)
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