50629-82-8

Basic information

• Product Name: Halometasone
• Synonyms: HALOMETASONE;HALOMETASONE HYDRATE;HALOMETASONE MONOHYDRATE;2-chlor-6a,9-difluor-11b,17,21-trihydroxy-16a-methyl-1,4-pregnadien-3,20-dion;2-chloroflumethasone;(6α，11β，16α)-2-Chloro-6，9-difluoro-11，17，21-trihydroxy-16-methylpregna-1，4-diene-3，20-dione;Halomethasone;Sicorten
• CAS NO: 50629-82-8
• Molecular Formula: C₂₂H₂₇ClF₂O₅
• Molecular Weight: 444.9
• EINECS: 256-664-9
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 50629-82-8.mol

Chemical Properties

• Melting Point: 220-222° (dec)
• Boiling Point: 600.538 °C at 760 mmHg
• Flash Point: 316.994 °C
• Appearance: /
• Density: 1.422 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Refrigerator
• Solubility: Acetone (Sparingly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.93±0.70(Predicted)
• CAS DataBase Reference: Halometasone(CAS DataBase Reference)
• NIST Chemistry Reference: Halometasone(50629-82-8)
• EPA Substance Registry System: Halometasone(50629-82-8)

Safety Data

• Hazardous Substances Data: 50629-82-8(Hazardous Substances Data)

Usage

Uses

Used in Dermatology:
Halometasone is used as a topical steroid for the treatment of skin disorders such as chronic eczema and psoriasis. Its potent anti-inflammatory and immunosuppressive properties help alleviate symptoms and promote skin healing without causing significant side effects.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Halometasone is utilized as an active ingredient in various formulations, such as creams, ointments, and lotions, targeting skin conditions that require potent anti-inflammatory and immunosuppressive action. Its inclusion in these products helps improve the effectiveness of treatments for a range of dermatological issues.

Originator

Ciba-Geigy (Switzerland)

InChI:InChI=1/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1

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