Welcome to LookChem.com Sign In|Join Free

CAS

  • or

50812-37-8

Glutathione S-Transferase (GST) is a crucial detoxification enzyme that exists in multiple forms as cytoplasmic and membrane-bound isozymes. These isozymes exhibit variations in their catalytic activity and non-catalytic binding properties. The cytoplasmic isoforms of GST are encoded by five genes: α, θ, μ, σ, and π, with α, μ, and π being the most prevalent in mammals. The membrane-bound GST forms are encoded by a single gene.

50812-37-8 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 50812-37-8 Structure

  • Basic information

    1. Product Name: GLUTATHIONE S-TRANSFERASE
    2. Synonyms: RX: GLUTATHIONE R-TRANSFERASE;PURIFIED GST;EC 2.5.1.18;GLUTATHIONE S-ALKENETRANSFERASE;GLUTATHIONE S-ALKYLTRANSFERASE;GLUTATHIONE S-ARALKYLTRANSFERASE;GLUTATHIONE S-ARYLTRANSFERASE;GLUTATHIONE S-EPOXIDETRANSFERASE
    3. CAS NO:50812-37-8
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 50812-37-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /lyophilized powder
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: GLUTATHIONE S-TRANSFERASE(CAS DataBase Reference)
    10. NIST Chemistry Reference: GLUTATHIONE S-TRANSFERASE(50812-37-8)
    11. EPA Substance Registry System: GLUTATHIONE S-TRANSFERASE(50812-37-8)

  • Safety Data

    1. Hazard Codes: B
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 50812-37-8(Hazardous Substances Data)

50812-37-8 Usage

Uses

Used in Antigen Microarray and Informatics Analysis:
Glutathione S-Transferase from human placenta is utilized as a key component in antigen microarray and informatics analysis. This application aids in the study of protein-protein interactions and the identification of potential biomarkers for various diseases, including cancer.
Used in Pharmaceutical Industry:
GST is employed as a detoxification agent in the pharmaceutical industry, where it plays a significant role in the metabolism and elimination of drugs and other xenobiotics. Its ability to conjugate with glutathione helps neutralize harmful substances, making it an essential tool in drug development and safety assessment.
Used in Environmental Toxicology:
In the field of environmental toxicology, GST is used as a biomarker for exposure to environmental pollutants and toxins. The enzyme's activity levels can indicate the extent of an organism's exposure to harmful substances, providing valuable information for assessing environmental health risks.
Used in Research and Development:
GST is also used in research and development for various applications, such as studying the mechanisms of drug resistance, understanding the role of GST in disease progression, and developing novel therapeutic strategies targeting GST-mediated pathways.

Biochem/physiol Actions

Glutathione S-transferase (GST) catalyzes conjugation reactions during phase II metabolism. This enzyme also confers protection against catabolic products of peroxidized lipid and oxidized DNA, and ROS (reactive oxygen species) or electrophiles.

Purification Methods

It is purified by affinity chromatography using a column prepared by coupling glutathione to epoxy-saturated Sepharose. After washing contaminating proteins, the pure transferase is eluted with buffer containing reduced glutathione. The solution is then concentrated by ultrafiltration, dialysed against phosphate buffer at pH ~7 and stored in the presence of dithiothreitol (2mM) in aliquots at <-20o. [Simons & Vander Jag Anal Biochem 52 334 1977.]

Check Digit Verification of cas no

The CAS Registry Mumber 50812-37-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,8,1 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 50812-37:
(7*5)+(6*0)+(5*8)+(4*1)+(3*2)+(2*3)+(1*7)=98
98 % 10 = 8
So 50812-37-8 is a valid CAS Registry Number.

50812-37-8Upstream product

50812-37-8Downstream Products

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 50812-37-8