508195-68-4Relevant articles and documents
4-(5-Chloro-2(3H)-benzoxazolon-3-yl) Butanoic Acid Derivatives: Synthesis, Antinociceptive and Anti-inflammatory Properties
Gulcan, Hayrettin Ozan,Kupeli, Esra,Unlu, Serdar,Yesilada, Erdem,Sahin, Mustafa Fethi
, p. 477 - 482 (2003)
In this study, 4-(5-chloro-2(3H)-benzoxazolone-3-yl)butanoic acid and its ethyl ester as well as its ten new amide derivatives have been synthesized. Their structures have been elucidated by IR, 1H-NMR spectra and elemental analysis. The compounds were screened for antinociceptive and anti-inflammatory activities. The highest antinociceptive and anti-inflammatory activities were exhibited by Compound 11 which has carboxylic acid structure. A various decrease in antinociceptive and anti-inflammatory activity was observed by amidation of the carboxylic acid moiety of this compound.