50850-18-5Relevant articles and documents
2--6-methylpyrimidin-4(3H)-ones. Novel Precursors for the Synthesis of Imidazopyrimidines and Imidazopyridines
Katagiri, Nobuya,Koshihara, Akemi,Atsuumi, Shugo,Kato, Tetsuzo
, p. 167 - 169 (1982)
2--6-methylpyrimidin-4-(3H)-ones, which are synthesized from β-aminocrotonamide and ethyl N-acylglycinates, have been found to be novel and versatile precursors for the synthesis of imidazopyrimidines and imidazopyridines.
Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpirimidin-4(3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)
Katagiri, Nobuya,Koshihara, Akemi,Atsuumi, Shugo,Kato, Tetsuzo
, p. 2288 - 2295 (2007/10/02)
Reaction of β-aminocrotonamide with N-acylated amino acid esters in the presence of sodium methoxide gave 2-acylaminoalkyl-6-methylpyrimidin-4(3H)-ones, some of wich, on treatment with polyphosphoric acid (PPA), were transformed into imidazopyrimidines and imidazopyridines.