50850-19-6Relevant articles and documents
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity
Jones, Jesse A.,Prior, Allan M.,Marreddy, Ravi K. R.,Wahrmund, Rebecca D.,Hurdle, Julian G.,Sun, Dianqing,Hevener, Kirk E.
, p. 1528 - 1535 (2019/07/09)
Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high, and multiple recurrences are not uncommon. Causes inc
4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
-
, (2013/03/26)
The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as fo
Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK
Kitagawa, Hideo,Ozawa, Tomohiro,Takahata, Sho,Iida, Maiko
, p. 4982 - 4986 (2008/03/13)
Novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae were synthesized and evaluated. Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors.
Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK
Ozawa, Tomohiro,Kitagawa, Hideo,Yamamoto, Yasuo,Takahata, Sho,Iida, Maiko,Osaki, Yumi,Yamada, Keiko
, p. 7325 - 7336 (2008/04/05)
Bacterial enoyl-acyl carrier protein (ACP) reductases (FabI and FabK) catalyze the final step in each cycle of bacterial fatty acid biosynthesis and are attractive targets for the development of new antibacterial agents. Here, we report the development of novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae. Based on structure-activity relationship (SAR) studies of our screening hits, we have developed novel phenylimidazole derivatives as potent FabK inhibitors.