The synthesis of mansonone E was completed in six steps and 34% overall yield from commercially available starting material 3-bromo-4-methyl acetophenone. The thermal ring expansion of a cyclobutenedione derivative followed by an intramolecular 1,3-alkoxy exchange provided a facile route to the 1,2-naphthoquinone tricyclic structure of mansonone E.
Fang, Xianhe,Hu, Xiangdong
p. 137 - 139
(2014/04/17)
Intramolecular Diels-Alder Additions of Benzynes to Furans. Application to the Total Synthesis of Biflorin, and the Mansonones E, I, and F
Benzynes, generated either by the debromination of an appropriately substituted o-dibromobenzene, or by the thermolysis of a substituted diazotized anthranilic acid, have been trapped intramolecularly by an attached furan moiety.One such adduct (41) has b
Best, Wayne M.,Wege, Dieter
p. 647 - 666
(2007/10/02)
INTRAMOLECULAR DIELS-ALDER REACTIONS OF BENZYNES APPLICATION TO THE TOTAL SYNTHESIS OF MANSONONE E
Substituted benzynes can be trapped intramolecularly by an attached furan moiety and such a reaction has been used in the synthesis of the naturally occuring o-naphthoquinone mansonone E.
Best, Wayne M.,Wege, Dieter
p. 4877 - 4880
(2007/10/02)
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