509152-20-9Relevant articles and documents
Investigation of the scope of a [3+2] cycloaddition approach to isoxazole boronic esters
Moore, Jane E.,Davies, Mark W.,Goodenough, Katharine M.,Wybrow, Robert A. J.,York, Mark,Johnson, Christopher N.,Harrity, Joseph P. A.
, p. 6707 - 6714 (2007/10/03)
The [3+2] cycloaddition reaction of nitrile oxides and alkynylboronates provides direct access to a wide variety of isoxazole boronic esters. Specifically, this technique has been employed to generate trisubstituted isoxazole 4-boronates and disubstituted isoxazoles where the boronic ester moiety can be installed at C-4 or C-5 with high levels of regiocontrol. The application of this methodology in the synthesis of non-steroidal antiinflammatory agents is also described.
Synthesis of 3-haloisoxazole boronic esters: Novel heterocyclic synthetic intermediates containing independently variable functionality
Moore, Jane E.,Goodenough, Katharine M.,Spinks, Daniel,Harrity, Joseph P.A.
, p. 2071 - 2073 (2007/10/03)
The regioselective cycloaddition reaction of nitrile oxides with alkynylboronates has been exploited in the preparation of 3-bromo- and 3-chloroisoxazolyl-4-boronates. The synthetic potential of these intermediates has been explored through a number of cr
