Expedient base-mediated desulfitative dimethylamination, oxidation, or etherification of 2-(Methylsulfanyl)-3,5-dihydro-4 H -imidazol-4-one scaffolds
The dimethylamino functionality is generally introduced onto the 3,5-dihydro-4H-imidazol-4-one skeleton by treatment of a halogenated derivative with low-boiling dimethylamine at a high temperature and pressure. The corresponding aliphatic ethers are usua
Khan, Shahnawaz,Tyagi, Vikas,Mahar, Rohit,Bajpai, Vikas,Kumar, Brijesh,Chauhan, Prem M.S.
p. 2405 - 2412
(2013/09/23)
Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors. Part 1
The series of glycine derivatives of diphenyl or (un)substituted arylidene imidazolones was designed and obtained as potential ligands of the glycine binding site of NMDA receptors. The compounds were evaluated in vitro for their affinity to the glycine b