Synthesis of 3-aryl-5-methyl 4-substituted [1,2,4]triazoles
Treatment of N -substituted acetamides with oxalyl chloride generates imidoyl chlorides, which react readily with aryl hydrazides. Following cyclization, triazoles can easily be obtained in moderate to good yields. 5-Methyl triazoles can be further functionalized through α-lithiation and subsequent reaction with an electrophile. Copyright Taylor & Francis Group, LLC.
Lindstroem, Johan,Johansson, Martin
p. 2217 - 2229
(2007/10/03)
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