- A two-photon fluorescent probe for lysosomal zinc ions
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The selective detection of zinc ions in lysosomes over that in cytosol is achieved with a fluorescent probe, which enabled the fluorescence imaging of endogenous zinc ions in lysosomes of NIH 3T3 cells as well as mouse hippocampal tissues by two-photon mi
- Lee, Hyo-Jun,Cho, Chang-Woo,Seo, Hyewon,Singha, Subhankar,Jun, Yong Woong,Lee, Kyung-Ha,Jung, Youngseob,Kim, Kyong-Tai,Park, Seongjun,Bae, Sung Chul,Ahn, Kyo Han
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supporting information
p. 124 - 127
(2015/12/26)
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- A highly selective and colorimetric naked-eye chemosensor for Cu2+
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A sample and practical colorimetric naked-eye chemosensor 3-nitro-4-ethylenediamido-nitrobenzene (2) for metal cations was designed and synthesized. It displays high selectivity and sensitivity for Cu2+ by the UV absorption which appeared a new peak at 525 nm and color change from yellow to red by naked-eye in CH3OH/H2O pH 7.6.
- Wang, Zhijun,Fan, Xiaojun,Li, Donghong,Feng, Liheng
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experimental part
p. 1224 - 1227
(2009/02/07)
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- Synthesis of selected novel covalently linked flavoquinolones
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The synthesis of novel covalently linked flavoquinolones via amide bond is described using mixed anhydride method and their spectroscopic studies have been done by UV/Vis and 1H NMR spectroscopic data. Georg Thieme Verlag Stuttgart.
- Singh, Ram,Geetanjali
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p. 2315 - 2320
(2007/10/03)
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- THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
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The invention provides a compound of formula (I) (where R1, R1’, R2, R3, X, Y, Z and n are disclosed herein) or a pharmaceutically acceptable salt thereof (s “Diaminoalkylene Compound”); pharmaceutical compositions comprising an effective amount of a Diaminoalkylene Compound; and methods for treating pain, as well as other conditions, comprising administering to an animal in need thereof an effective amount of a Diaminoalkylene Compound.
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Page/Page column 111
(2008/06/13)
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- Aryl piperidine amides
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The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.
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Page/Page column 16-17
(2010/02/11)
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- Sulfonyldihydrobenzimidazolone compounds as 5-hydroxytryptamine-6 ligands
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The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
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Page/Page column 9
(2008/06/13)
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- Design and synthesis of new ethylenediamine or propylenediamine diacetic acid derivatives for Re(I) organometallic chemistry
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A general synthetic approach for a novel range of bifunctional chelating agent (BCA) for the 'fac-[M(CO)3]+' core (M= 99mTc, 99Tc or Re) has been developed. The strategy includes the facile preparation of these tridentate ligands possessing a tertiary amine bearing two carboxylic acid functions as coordinating site and an aromatic amino group for coupling to a biovector. First complexation study has shown that these compounds act exclusively as tridentate ligands (via the two acids and the tertiary amine functions). The convenient synthesis of these new ligands coupled with their high affinity for Re(I) make them quite promising for biomedical applications.
- Allali, Mustapha,Benoist, Eric,Habbadi, Nouzha,Gressier, Marie,Souizi, Abdelaziz,Dartiguenave, Michèle
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p. 1167 - 1174
(2007/10/03)
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- Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives.
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A series of benzoylpiperidine analogs related to 4a was prepared, and their ability to inhibit the uptake of [(14)C]-glycine in COS7 cells transfected with human glycine transporter type-2 (GlyT-2) was evaluated. Small structural changes to the benzoylpiperidine region of the molecule led to a significant decrease in GlyT-2 inhibitory activity. In contrast, the distal aryl ring was more tolerant to functional group modifications and could accommodate a variety of substitutes at the C-2 or C-3 positions. Comparable activities to 4a were obtained by replacing the anilino nitrogen with an ether linkage 27 or by exchanging the isopropoxy ether moiety with an isopropyl amino group 15. A distinct preference for a 2-carbon tether (n=1) was observed relative to the corresponding 3-carbon homolog (n=2).
- Wolin, Ronald L,Santillan Jr., Alejandro,Tang, Liu,Huang, Charles,Jiang, Xiaoxia,Lovenberg, Timothy W
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p. 4511 - 4532
(2007/10/03)
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- Studies on the novel anti-staphyloccal compound nematophin
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A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Kennedy, Gordon,Viziano, Monica,Winders, John Alexander,Cavallini, Palmina,Gevi, Monica,Micheli, Fabrizio,Rodegher, Pamela,Seneci, Pierfausto,Zumerle, Aurelia
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p. 1751 - 1754
(2007/10/03)
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- Unusual reaction of 1,4-diamino-2-nitrobenzene derivatives toward nucleophiles: Catalysis by sodium sulphite
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Unusual substitution of amino group occurs by reactions of some 1,4diamino-2-nitrobenzenes (semipermanent hair dyes) and nucleophiles (NH3, H2O). The reaction is catalyzed by sodium sulfite. The obtained products are suspected of being toxic substances which may be present in cosmetic matrices. Apparently, this reaction is a nucleophilic aromatic substitution but it may be explained by a mechanism involving a tautomeric form of substrate.
- Forlani, Luciano,Boga, Carla,Mazza, Milena,Cavrini, Vanni,Andrisano, Vincenza
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p. 4647 - 4654
(2007/10/03)
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- Mechanism and Kinetics of Reactions of 2-Nitrofluorobenzene with Aliphatic Amines
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The reaction rates of 2-nitrofluorobenzene with some amines in toluene and in dimethyl sulfoxide have been measured.The moderate autocatalytic behaviour, the small solvent effect and the absence of a kinetic salt effect suggest a transition state with a s
- Boga, Carla,Forlani, Luciano,Guardia, Patrizia
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p. 259 - 262
(2007/10/03)
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