A Simple, efficient, Catalyst-Free and Solvent-Less Microwave-Assisted process for N-Cbz Protection of Several amines
A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, β-amino alcohols, α-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxy-carbamates compounds were obtained in short times without any side products.
Electrochemical deallylation of α-allyl cyclic amines and synthesis of optically active quaternary cyclic amino acids
Electrochemical oxidation of α-allylated and α-betizylated N-acylated cyclic amines by using a graphite anode easily affords the corresponding α-methoxylated products with up to 76% yield. Ease of oxidation was affected by the type of electrode, the size
Kirira, Peter G.,Kuriyama, Masami,Onomura, Osamu
scheme or table
p. 3970 - 3982
(2010/07/04)
Synthetic studies towards proline amide isosteres, potentially useful molecules for biological investigations
2-Ethenylpyrrolidine derivative 8b was prepared from N-protected proline ethyl ester 6b. Bromofluorination of 8b wth NBS-Bu4NF/2HF gave a 1:1 regioisomeric mixture, 9b and 10b (X = Br). Dehydrobromination of 9b and 10b with t-BuOK produced a fluoroolefin 11 and a proline amide isostere model 12, respectively. Deprotection of the Z group in 12 was attempted by treatment with CF3COOH. Although formation of the useful molecule is pseudopeptide synthesis, 13, was observed as checked by NMR spectra, it seemed to decompose slowly during purification procedure to give a mixture of fluorine-free compounds.
Takeuchi,Yamada,Suzuki,Koizumi
p. 225 - 232
(2007/10/02)
A Simple One-Step Conversion of Carboxylic Acids to Esters Using EEDQ
-
Zacharie, Boulos,Connolly, Timothy P.,Penney, Christopher L.
p. 7072 - 7074
(2007/10/03)
More Articles about upstream products of 51207-69-3