Synthesis and study of some compounds containing oxazolone ring, showing biological activity
Synthesis of the oxazolone ring has been performed by the condensation of 4-substituted alkoxy benzoyl glycine with appropriate 4-substituted alkoxy benzaldehyde, in the presence of acetic anhydride and anhydrous sodium acetate. The antibacterial activity has been checked against Micrococcus luteus and Escherichia coli and antifungal activity against Alternaria alternate and Phoma multirostata for all the compounds. The cytotoxicity has been checked against the monocots barley seeds: Hordeum vulgare L and dicots moong seeds; Phaseolus aureus. The compounds having electron releasing group exhibit antibacterial activity. Compounds with nitro group cause total inhibition of seed germination, exhibiting cytotoxic behaviour. The structures of the synthesized compounds have been characterized by elemental analysis and spectral data and the purity of the compounds has been checked by TLC method.
Tandel,Mammen, Denni
p. 932 - 937
(2008/12/23)
Solid-phase synthesis of aryl ethers on high loading dendrimer resin
Resin-bound dendrimers have the potential to increase bead loading by at least one order of magnitude. In this letter we report the solid-phase synthesis of a library of aryl ethers using high-loading dendrimer beads, and compare the synthetic efficiency with that of TentaGel (Polystyrene-PEG) resin. (C) 2000 Elsevier Science Ltd.
Basso, Andrea,Evans, Brian,Pegg, Neil,Bradley, Mark
p. 3763 - 3767
(2007/10/03)
Polymer-Supported Mitsunobu Ether Formation and its Use in Combinatorial Chemistry
Aromatic hydroxy acids have been attached to a polymeric solid support and the phenolic hydroxy groups have been reacted with a variety of primary and secondary alcohols under the conditions of the Mitsunobu reaction (triphenylphosphine and diethyl azodicarboxylate) in tetrahydrofuran.In most cases the reaction provided a nearly quantitative yield of alkyl aryl ethers, as determined after cleaving theproduct from the resin.To demonstrate that the polymer-supported Mitsunobu reaction is useful for combinatorial library synthesis, we synthesized a number of model compounds and a simple three randomization step library composed of 4,200 different compounds.
Krchnak, Viktor,Flegelova, Zuzka,Weichsel, Aleksandra S.,Lebl, Michal
p. 6193 - 6196
(2007/10/02)
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