512810-25-2

Basic information

• Product Name: 1H-Pyrazole-4-carboxylicacid,1,3-dimethyl-,hydrazide(9CI)
• Synonyms: 1H-Pyrazole-4-carboxylicacid,1,3-dimethyl-,hydrazide(9CI)
• CAS NO: 512810-25-2
• Molecular Formula: C6H10N4O
• Molecular Weight: 154.17
• Product Categories: HYDRAZIDE;AMIDE
• Mol File: 512810-25-2.mol

Chemical Properties

• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 12.18±0.10(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-4-carboxylicacid,1,3-dimethyl-,hydrazide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylicacid,1,3-dimethyl-,hydrazide(9CI)(512810-25-2)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylicacid,1,3-dimethyl-,hydrazide(9CI)(512810-25-2)

Safety Data

• Hazardous Substances Data: 512810-25-2(Hazardous Substances Data)

Usage

Compound type

hydrazide derivative of pyrazole carboxylic acid

Common uses

building block in the synthesis of pharmaceuticals and other organic compounds

Properties

antifungal, antibacterial

Potential uses

inhibitor of enzyme activity

New material development

unique chemical structure and properties

Upstream product

• 85290-76-2 1-methyl-3-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 137024-37-4 methyl (2E)-2-(ethoxymethylidene)-3-oxobutanoate 

Relevant articles and documents

[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES

The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. The compound structures were confirmed by melting point, 1H NMR and HRMS. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

Synthesis and Herbicidal Activity of 1,2,4-Triazole Derivatives Containing a Pyrazole Moiety

A series of triazole derivatives containing a pyrazole moiety were synthesized and characterized by 1H NMR, 13C NMR, and HRMS. The herbicidal activities of these compounds were tested against lettuce and bentgrass. Most of the tested compounds were moderately herbicidal activity against lettuce and bentgrass. Among them, compounds 6f and 6g had the highest herbicidal activity (80% inhibitory) against lettuce and bentgrass.

Triazole compound containing methylpyrazole and preparation method and application thereof

The invention relates to a triazole compound containing methylpyrazole and a preparation method and application of the triazole compound containing methylpyrazole. The triazole compound containing methylpyrazole is a 5-(1-methyl-3-methyl-1H-pyrazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thioether compound. The compound can be applied to herbicides for radish, cucumber, rape, wheat, sorghum, barnyard grass and the like, and the compound is a novel compound with herbicidal activity, and lays a foundation for research and development of novel pesticides.

Application of 1,3,4-thiadiazole thioether derivative in preparing herbicide

The invention discloses application of a 1,3,4-thiadiazole thioether derivative in preparing herbicide. A compound (I-1) and a compound (I-14) of the compound at the concentration of 100 micrograms/mL have good activity on wheat, sorghum, barnyard grass, cucumbers, rape and radishes, and the compound I-1, a compound I-9, a compound I-13 and the compound I-14 can achieve the suppression ratio of higher than 80% on winter rape and radishes. The compounds are new and have the herbicidal activity, and a basis is provided for research and development of new pesticides.

1,3,4-thiadiazole thioether derivative, and preparation method and applications thereof

The invention discloses a 1,3,4-thiadiazole thioether derivative, and a preparation method and applications thereof. The 1,3,4-thiadiazole thioether derivative is 5-(4-(1,3-dimethyl-1H-pyrazol))-1,3,4-thiadiazole-2-thioether derivative, and possesses certain inhibition effects on botrytis cinerea, colletotrichum orbiculare, botryospuaeria berengeriana, and rhizoctonia solani at a concentration of 20g/ml; inhibition ratio of a compound (I-10) on colletotrichum orbiculare is 43.06%. The 1,3,4-thiadiazole thioether derivative is a novel compound with antibacterial activity, and foundation is provided for development of new pesticides.

Application of triazole compound containing methylpyrazole to bactericide preparation

The invention relates to the application of a triazole compound containing methylpyrazole to bactericide preparation. The triazole compound containing methylpyrazole is a 5-(1-methyl-3-methyl-1H-pyrazol-4-base)-4-phenyl-4H-1,2,4-triazole-3-thioether compound. Specifically, a bactericide prepared from the compound has a remarkable effect when used for controlling rice sheath blight disease, tomato early blight, cucurbits anthracnose and cucumber gray mold. The compound is a novel compound with bactericidal activity, and a basis is provided for research and development of novel pesticides.