512822-50-3

Basic information

• Product Name: N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID
• Synonyms: N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID;1-N-Boc-3-methyl-piperidine-4-carboxylic acid;1-(tert-Butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid;1,4-Piperidinedicarboxylic acid, 3-methyl-, 1-(1,1-dimethylethyl) ester
• CAS NO: 512822-50-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: pharmacetical
• Mol File: 512822-50-3.mol

Chemical Properties

• Boiling Point: 359.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.121±0.06 g/cm3(Predicted)
• PKA: 4.57±0.40(Predicted)
• CAS DataBase Reference: N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID(512822-50-3)
• EPA Substance Registry System: N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID(512822-50-3)

Safety Data

• Hazardous Substances Data: 512822-50-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-BOC-3-METHYL-4-PIPERIDINECARBOXYLIC ACID is used as a key intermediate for the synthesis of indazole and pyrrolopyridine derivatives, which are known for their potential therapeutic effects in treating Alzheimer-type dementia. These derivatives act as 5-HT4 receptor agonists, modulating the neurotransmission process and potentially improving cognitive function in patients with dementia.
Additionally, the compound may be utilized in the development of other pharmaceutical products targeting various neurological and psychiatric disorders, given its role in the synthesis of bioactive molecules.

Upstream product

• 512822-18-3 C₁₂H₂₁NO₃ 
• 1207267-93-3 1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid 
• 1038992-98-1 3-methylpiperidine-4-carboxylic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 577993-80-7 3-methylpyridine-4-carboxylic acid hydrochloride 
• 577993-80-7 3-methylpyridine-4-carboxylic acid hydrochloride 
• 116985-92-3 Methyl 3-methylpyridine-4-carboxylate 
• 885951-69-9 3-methylpiperidine-4-carboxylic acid 
• 1824505-67-0 1-tert-butyl 4-methyl 3-methylpiperidine-1,4-dicarboxylate 
• 4021-12-9 3-methyl-isonicotinic acid 

Downstream Products

• 1082950-49-9 4-[4-(4-fluoro-3-trifluoromethylphenyl)-1H-imidazol-2-yl]-3-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 1207267-93-3 (3R,4R)-1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid 
• 1207267-93-3 (3S,4S)-1-(tert-butoxycarbonyl)-3-methylpiperidine-4-carboxylic acid 

Relevant articles and documents

SUBSTITUTED 4-PIPERIDINYL-QUINAZOLINES, 4-PIPERIDINYL-PYRIMIDINE-2-AMINES, AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS

The invention provides substituted 4-piperidinyl-quinazolines, 4-piperidinyl-pyrimidine-2-amines, and related compounds, pharmaceutical compositions, their use for inhibiting ERK5 activity, and their use in the treatment of medical disorders, such as cancer.

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

THERAPEUTIC METHODS AND COMPOUNDS

The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.

COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLIC DISEASE

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLIC DISEASE

Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

2′ Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR

Biaryl amides were discovered as novel and subtype selective M1 muscarinic acetylcholine receptor agonists. The identification, synthesis, and initial structure-activity relationships that led to compounds 3j and 4c, possessing good M1 agonist potency and intrinsic activity, and subtype selectivity for M1 over M2-5, are described.

2′ Biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling

Further optimization of the biaryl amide series via extensively exploring structure-activity relationships resulted in potent and subtype selective M 1 agonists exemplified by compounds 9a and 9j with good rat PK properties including CNS penetration. Synthesis, structure-activity relationships, subtype selectivity for M1 over M2-5, and DMPK properties of these novel compounds are described.

1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

ANTI-INFLAMMATORY COMPOUNDS

The use of a steroid sulfatase inhibitor in the preparation of a medicament for the treatment of inflammatory diseases.

COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN

A combination of a steroid sulfatase inhibitor and an ascomycin, which combination is useful as a pharmaceutical.