- Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold
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A series of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold were designed, synthesized and evaluated for their in vitro antiproliferative activities against human cancer cell lines SMMC-7721, Hela, A549, and normal cell lines L
- Li, Bao-Lin,Li, Bo,Zhang, Rui-Lian,Zhao, Ji-Jun,Wang, Xue-Feng,Liu, Yu-Ming,Shi, Yan-Ping,Liu, Jin-Biao,Chen, Bao-Quan
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p. 1279 - 1281
(2016/02/23)
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- Synthesis of novel derivatives of 3(5)-alkylsulfonyl-1,2,4-triazoles
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The feasibility of preparing novel 1,2,4-triazole derivatives bearing alkylsulfonyl and other functional groups on the ring carbon atom has been demonstrated. The syntheses are carried out via transformation of the amino group of 3(5)-alkylsulfonyl-5(3)-amino-1,2,4-triazoles into other functional groups.
- Tolstyakov,Pevzner,Tselinskii
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p. 1458 - 1465
(2007/10/03)
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- On Triazoles. I. The reaction of N-Cyanocarbonimidodithioic Acid Diesters With Hydrazines
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The reaction of N-cyanocarbonimidodithioic acid di(alkyl and aralkyl)esters with different alkyl-, aralkyl- and aryl hydrazines to yield 1-substituted-3-R-thio-5-amino-1H-1,2,4-triazoles (3) and 2-substituted-3-R-thio-5-amino-2H-1,2,4-triazoles (4) was studied.Isolation of the different types of isomeric pairs of 3 and 4 helped to prove the structure of products obtained which made possible correction of some confusion in the literature.The 3 (R = H) tautomeric structure of the non-substituted derivatives was supported by comparison of their uv and cmr spectra with those of the alkylated and aralkylated derivatives 3 and 4, respectively, again correcting confusion in literature.An hplc determination of the ratio of products 3 and 4 formed in the above reactions with different hydrazines made it possible to prove the mechanism of the reaction.
- Reiter, J.,Somorai, T.,Jerkovich, Gy.,Dvortsak, P.
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p. 1157 - 1164
(2007/10/02)
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