- Preparation method of 1,2-di-fatty acyl-sn-glycerol-3-phosphatidylserine
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The invention provides a preparation method of 1,2-bis (fatty acyl)-sn-glycerol-3-phosphatidylserine. The method comprises the following steps: enabling (S)-glyceryl acetonide, bis(diisopropyl amino)(trichloroethoxy) phosphine and N-Troc-serine benzyl ester to react and oxidize to obtain 1,2-O-isopropylidene-glycerol-3-phosphoryl-N-Troc-serine benzyl ester; carrying out hydrolysis reaction on the 1,2-O-isopropylidene-glycerol-3-phosphoryl-N-Troc-serine benzyl ester to obtain 2,3-dihydroxy propyl-1-phosphoryl-N-Troc-serine benzyl ester; enabling 2,3-dihydroxypropyl-1-phosphoryl-N-Troc-serine benzyl ester and fatty acid to be subjected to a condensation reaction to obtain 1,2-difatty acyl-sn-glycerol-3-phosphoryl-N-Troc-serine benzyl ester; carrying out hydrogenation reaction on the 1,2-di-fatty acyl-sn-glycerol-3-phosphoryl-N-Troc-serine benzyl ester to obtain 1,2-di-fatty acyl-sn-glycerol-3-phosphoryl-N-Troc-serine; and carrying out a deprotection reaction on the 1,2-difatty acyl-sn-glycerol-3-phosphoryl-N-Troc-serine to obtain the 1, 2-difatty acyl-sn-glycerol-3-phosphatidylserine.
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