515880-75-8

Basic information

• Product Name: N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
• Synonyms: N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine;4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
• CAS NO: 515880-75-8
• Molecular Formula: C24H24N4O2
• Molecular Weight: 400.47296
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 515880-75-8.mol

Chemical Properties

• Appearance: off-white to brown/
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble20mg/mL
• PKA: 6.28±0.10(Predicted)
• CAS DataBase Reference: N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine(515880-75-8)
• EPA Substance Registry System: N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine(515880-75-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 515880-75-8(Hazardous Substances Data)

Usage

Uses

Used in Anticancer Applications:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as an anticancer agent for its ability to inhibit the growth of certain human lung cancer cells (H460 and A549) and reduce VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs). Its antiangiogenic properties make it a potential candidate for targeting tumor growth and progression by disrupting the formation of new blood vessels that supply nutrients to the tumor.
Used in Pharmaceutical Research:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as a research compound for studying the role of VEGFR2 in various cellular processes and its potential as a therapeutic target in cancer and other angiogenesis-dependent diseases. Its selective inhibition of VEGFR2 over other receptors makes it a valuable tool in understanding the specific pathways involved in these conditions.
Used in Drug Development:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as a lead compound in the development of new drugs targeting VEGFR2 for the treatment of cancer and other related diseases. Its potent and selective inhibition of VEGFR2 makes it a promising starting point for the design and synthesis of more effective and specific therapeutic agents.