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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine, also known as DMH4, is a selective inhibitor of VEGF receptor 2 (VEGFR2) and a derivative of dorsomorphin. It is characterized by its ability to selectively inhibit VEGFR2 over other receptors such as activin receptor-like kinase 2 (ALK2), ALK5, and AMPK. DMH4 has demonstrated antiangiogenic activity both in vitro and in vivo, making it a promising compound for various applications in the medical field.

515880-75-8

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515880-75-8 Usage

Uses

Used in Anticancer Applications:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as an anticancer agent for its ability to inhibit the growth of certain human lung cancer cells (H460 and A549) and reduce VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs). Its antiangiogenic properties make it a potential candidate for targeting tumor growth and progression by disrupting the formation of new blood vessels that supply nutrients to the tumor.
Used in Pharmaceutical Research:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as a research compound for studying the role of VEGFR2 in various cellular processes and its potential as a therapeutic target in cancer and other angiogenesis-dependent diseases. Its selective inhibition of VEGFR2 over other receptors makes it a valuable tool in understanding the specific pathways involved in these conditions.
Used in Drug Development:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine is used as a lead compound in the development of new drugs targeting VEGFR2 for the treatment of cancer and other related diseases. Its potent and selective inhibition of VEGFR2 makes it a promising starting point for the design and synthesis of more effective and specific therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 515880-75-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,5,8,8 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 515880-75:
(8*5)+(7*1)+(6*5)+(5*8)+(4*8)+(3*0)+(2*7)+(1*5)=168
168 % 10 = 8
So 515880-75-8 is a valid CAS Registry Number.

515880-75-8 Well-known Company Product Price

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  • Sigma

  • (D8696)  DMH4  >99.0% (HPLC)

  • 515880-75-8

  • D8696-5MG

  • 1,400.49CNY

  • Detail
  • Sigma

  • (D8696)  DMH4  >99.0% (HPLC)

  • 515880-75-8

  • D8696-25MG

  • 5,658.12CNY

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515880-75-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine

1.2 Other means of identification

Product number -
Other names DMH4

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:515880-75-8 SDS

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