- Phycomysterols and other sterols from the Fungus phycomyces blakesleeanus
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In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.
- Barrero,Enrique Oltra,Poyatos,Jimenez,Oliver
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p. 1491 - 1496
(2007/10/03)
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