- Novel synthetic method for rebamipide intermediate
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The invention discloses a novel synthetic method for a rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid. The method comprises a step of reacting aspartic acid with 2-hydroxyquinoline to prepare the key rebamipide intermediate, i.e., 2-amino-3-[2(1H)-quinolone-4]propionic acid; and the key rebamipide intermediate and p-chlorobenzoyl chloride undergo a condensation reactionso as to prepare rebamipide. The synthetic method for the intermediate has the advantages of low cost and easy availability of raw materials, short reaction steps and good optical purity.
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Paragraph 0014-0018
(2018/09/08)
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- PROCESS FOR PRODUCTION OF CARBOSTYRIL COMPOUND
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Disclosed is an improved process which can produce a carbostyril compound of the formula (1) or a salt thereof, which is useful as a pharmaceutical agent, more safely with higher efficiency. An improved process for producing a carbostyril compound comprising the steps of adding a high boiling solvent to a compound of the formula (4) and refluxing the resulting mixture under heating in hydrochloric acid to produce a compound of the formula (5) safely and acylating the compound of the formula (5) to produce a carbostyril compound of the formula (1).
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Page/Page column 11-12
(2008/06/13)
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