51655-56-2Relevant articles and documents
BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
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Paragraph 00335; 00357, (2021/04/01)
The application relates to lipids of Formula (A), Formula (B) and Formula (1-1), and to lipid nanoparticles (empty or loaded LNPs) including such a lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
LNP COMPOSITIONS COMPRISING MRNA THERAPEUTICS WITH EXTENDED HALF-LIFE
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Page/Page column 306; 0307; 308, (2022/01/04)
The disclosure features a polynucleotide encoding a polypeptide, which polynucleotide comprises: a 5'UTR described herein; a coding region comprising a payload and a stop element described herein; and a 3'UTR described herein, and LNP compositions comprising the same. The polynucleotides and/or LNP compositions of the present disclosure can: increase the level and/or activity of the payload by increasing the half-life and/or duration of expression of the polynucleotide encoding the payload or of the payload polypeptide. Also disclosed herein are methods of treating a disease or disorder in a subject using the LNP compositions of the present disclosure.
Synthetic method for gamma-dialkyl bromopropane
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Paragraph 0018, (2018/06/15)
The invention discloses a synthetic method for gamma-dialkyl bromopropane. The method is characterized by comprising the following steps: step 1, in the presence of an alkali, a compound I and triethyl phosphonoacetate are subjected to a Horner-Wadsworth-Emmons reaction to form a compound II; step 2, the compound II and palladium on carbon are subjected to a hydrogenation reduction reaction to form a compound III; step 3, the compound III is subjected to a reduction reaction under the action of NaBH4 to form a compound IV; and step 4, the compound IV and a bromide are subjected to a substitution reaction to form the compound V. The method provided by the invention has the characteristics of having a short route, wide applicability, relatively mild reaction conditions, a high reaction yield, and low costs, and being suitable for industrial scale-up production.
RECHERCES SUR LES SUBSTANCES MESOMORPHES-IX; SMECTIQUES "FOURCHUS". ORGANISATION MOLECULAIRE DANS LES PHASES SMECTIQUES
Malthete, Jacques,Canceill, Josette,Gabard, Jacqueline,Jacques, Jean
, p. 2823 - 2828 (2007/10/02)
The synthesis and the mesomorphic properties of new branched smectogenic A derivatives of fluorene are described.The observation that branched chain compounds from a smectic A phase allows conclusions to be drawn on molecular arrangements in smectic A layers.