- Novel Ring Cleavage Based on Intermolecular Aldol Condensation
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Ring cleavage and reconstruction via intramolecular aldol condensation followed by Grob fragmentation under acetalization conditions (BF3/ethylene glycol) was developed into a novel ring cleavage based on intermolecular aldol condensation.On the basis of
- Nagumo, Shinji,Matsukuma, Aki,Suemune, Hiroshi,Sakai, Kiyoshi
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p. 10501 - 10510
(2007/10/02)
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- Synthesis of Trialkylacetic Acids by the Anodic Oxidation of 3,3-Disubstituted-2-oxo Carboxylic Acids
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The "non-Kolbe" electrolysis of 3,3-disubstituted-2-oxocarboxylates 1-3 in methanol produced mixtures of methyl trialkylacetates 5, trialkylacetaldehydes 6, in some cases 2-hydroxy-3,3,3-trialkylpropionic acids 7, trialkylethylenes 8, and methyl trialkylmethyl ethers 9.When one of the substituents on the 3-carbon of the 2-oxo carboxylate was phenyl 4, molecular rearrangement was not observed.In addition to products 5-9, with the exception of 7, there was obtained with 4 an alkyl phenyl ketone 10.The methyl trisubstituted acetates were saponified to the desired trialkylacetic acids.
- Rabjohn, Norman,Cranor, W. L.,Schofield, C. M.
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p. 1732 - 1736
(2007/10/02)
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