- Stem Cell Culture Methods
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The invention provides methods for reversibly inhibiting stem cell differentiation wherein a compound of formula (I) is contacted with a stem cell. The invention further provides a method for preparing a culture medium, a culture medium supplement and a composition comprising a compound of formula (I).
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- Electrochemical Oxidation of Allenic Hydrocarbons in Acetonitrile
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The anodic oxidation of a variety of alkyl-substituted allenes, terminal and internal ones, has been investigated in acetonitrile. All compounds studied were found to undergo 2e(-) oxidation followed by nucleophilic attack by acetonitrile and water molecules, to form products containing at least two of the following functional groups, C=C, NHCOCH3, C=O, and OH.The effect of various parameters (concentration, electrolyte, oxidation potential, temperature, and anode material) on the electro-oxidation of a model compound (nona-1,2-diene) has been studied and a general mechanistic scheme is presented and discussed.
- Becker, James Y.,Zinger, Baruch
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p. 395 - 402
(2007/10/02)
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- Method of imparting immunomodulating and antiviral activity
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Compounds of the formula STR1 where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula STR2 where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
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- 9-(Hydroxy alkyl)purines
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There are prepared compounds of the formula STR1 where X is OH, R2 is CH3 and R1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.
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