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51787-31-6

Calonysterone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 51787-31-6 Structure

  • Basic information

    1. Product Name: Calonysterone
    2. Synonyms: (20R,22R)-2β,3β,6,20,22,25-Hexahydroxy-5,8,14-cholestatrien-7-one;Calonysterone
    3. CAS NO:51787-31-6
    4. Molecular Formula: C27H40O7
    5. Molecular Weight: 476.6023
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 51787-31-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Calonysterone(CAS DataBase Reference)
    10. NIST Chemistry Reference: Calonysterone(51787-31-6)
    11. EPA Substance Registry System: Calonysterone(51787-31-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 51787-31-6(Hazardous Substances Data)

51787-31-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 51787-31-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,8 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 51787-31:
(7*5)+(6*1)+(5*7)+(4*8)+(3*7)+(2*3)+(1*1)=136
136 % 10 = 6
So 51787-31-6 is a valid CAS Registry Number.

51787-31-6Downstream Products

51787-31-6Relevant articles and documents

Base-catalyzed autoxidation of 20-hydroxyecdysone: Synthesis of calonysterone and 920-dihydroxyecdysone

Suksamrarn, Apichart,Ganpinyo, Penpan,Sommechai, Chatriwat

, p. 4445 - 4448 (1994)

Base-catalyzed autoxidation of 20-hydroxyecdysone (2) gave an unusually modified ecdysteroid calonysterone (1) and 9,20-dihydroxyecdysone (4).

Oxidized Metabolites of 20-Hydroxyecdysone and Their Activity on Skeletal Muscle Cells: Preparation of a Pair of Desmotropes with Opposite Bioactivities

Csábi, József,Hsieh, Tusty-Jiuan,Hasanpour, Feria,Martins, Ana,Kele, Zoltán,Gáti, Tamás,Simon, András,Tóth, Gábor,Hunyadi, Attila

, p. 2339 - 2345 (2015)

Increasing the activation of protein kinase B (Akt) has been suggested as a key signaling step in the nonhormonal anabolic activity of the phytoecdysteroid 20-hydroxyecdysone (20E) in mammals. Base-catalyzed autoxidation of this compound was shown previously to yield interesting B-ring-modified analogues. Herein is reported a thorough study on this reaction, resulting in the preparation and complete NMR spectroscopic assignments of calonysterone (5) and its previously overlooked desmotropic pair (7), along with two new sensitive metabolites of 20E. The two isomers showed considerable stability in solution. Time dependency of the reaction for yield optimization is also presented; by means of analytical HPLC, the two desmotropes can reach a maximum combined yield of >90%. The activity of these compounds on Akt phosphorylation was tested in murine skeletal muscle cells. Compounds 2 and 5 showed more potent activity than 20E in increasing Akt activation, while compound 7 exerted an opposite effect. As such, the present study provides the first direct evidence for a pair of desmotropes exerting significantly different bioactivities.

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